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Crystal structure of CREBBP bromodomain complexd with PA10

X-ray diffraction
2.1Å resolution
PDB entry 6frf coloured by chain, front view.
PDB entry 6frf coloured by chain, side view.
PDB entry 6frf coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: CREB-binding protein
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Multimeric state: monomeric
Accessible surface area: 7263.81 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-187751
Assembly 2
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Assembly Name: CREB-binding protein
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Multimeric state: monomeric
Accessible surface area: 6614.96 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-187751
Assembly 3
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Assembly Name: CREB-binding protein
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Multimeric state: monomeric
Accessible surface area: 6664.96 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-187751
Assembly 4
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Assembly Name: CREB-binding protein
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Multimeric state: monomeric
Accessible surface area: 6696.83 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-187751

Macromolecules

CREB-binding protein
Chains: A, B, C, D
Length: 119 amino acids
Theoretical weight: 14.22 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q92793 (Residues: 1081-1197; Coverage: 5%)
Gene names: CBP, CREBBP
Pfam: Bromodomain
InterPro:
CATH: Bromodomain-like
CREB-binding protein in PDB entry 6frf, assembly 1, front view.
CREB-binding protein in PDB entry 6frf, assembly 1, side view.
CREB-binding protein in PDB entry 6frf, assembly 1, top view.
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