› 6fqi

X-ray diffraction
2.91Å resolution

GluA2(flop) G724C ligand binding core dimer bound to L-Glutamate (Form B) at 2.91 Angstrom resolution

Released:
DOI: 10.2210/pdb6fqi/pdb
PDB 6fqi coloured by chain and viewed from the front.
PDB 6fqi coloured by chain and viewed from the side.
PDB 6fqi coloured by chain and viewed from the top.
Source organism: Rattus norvegicus
Primary publication:
Homomeric GluA2(R) AMPA receptors can conduct when desensitized.
Coombs ID, Soto D, McGee TP, Gold MG, Farrant M, Cull-Candy SG
OpenAccess logo Nat Commun 10 4312 (2019)
PMID: 31541113

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutamate receptor 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 264 amino acids
Theoretical weight: 29.32 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli K-12
UniProt:
  • Canonical: P19491 (Residues: 413-527, 653-797; Coverage: 30%)
Gene names: Glur2, Gria2
Sequence domains:
Structure domains: Periplasmic binding protein-like II

Ligands and Environments

1 bound ligand:
Ligand GGL 2 x GGL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04
Spacegroup: P41
Unit cell:
a: 50.65Å b: 50.65Å c: 256.29Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.216 0.214 0.267
Expression system: Escherichia coli K-12

Quick links

Citations

1 review citation

Structure, Function, and Pharmacology of Glutamate Receptor Ion Channels.
Hansen et al. (2021)
1 other article