6fp4

X-ray diffraction
2.5Å resolution

Thioredoxin glutathione reductase from Schistosoma mansoni in complex with 1,8-Naphthyridine-2-carboxylic acid

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutaredoxin domain-containing protein Chain: A
Molecule details ›
Chain: A
Length: 598 amino acids
Theoretical weight: 65.11 KDa
Source organism: Schistosoma mansoni
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: G4V8J4 (Residues: 1-598; Coverage: 100%)
Gene name: Smp_048430
Sequence domains:

Ligands and Environments


Cofactor: Ligand FAD 1 x FAD
1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: ELETTRA BEAMLINE 5.2R
Spacegroup: C2
Unit cell:
a: 142.316Å b: 101.584Å c: 58.783Å
α: 90° β: 112.78° γ: 90°
R-values:
R R work R free
0.197 0.195 0.229
Expression system: Escherichia coli BL21(DE3)