6foh

X-ray diffraction
1.56Å resolution

X-ray structure of homo sapiens Fumarylacetoacetate hydrolase domain containing protein 1 (FAHD1) at 1.56A resolution.

Released:

Function and Biology Details

Reactions catalysed:
A 3-acylpyruvate + H(2)O = a carboxylate + pyruvate
Oxaloacetate = pyruvate + CO(2)
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
PDBe Complex ID:
PDB-CPX-180122 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Oxaloacetate decarboxylase, mitochondrial Chains: A, B
Molecule details ›
Chains: A, B
Length: 224 amino acids
Theoretical weight: 24.87 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q6P587 (Residues: 1-224; Coverage: 100%)
Gene names: C16orf36, FAHD1, YISKL
Sequence domains: Fumarylacetoacetate (FAA) hydrolase family
Structure domains: Fumarylacetoacetase-like, C-terminal domain

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE MASSIF-1
Spacegroup: P212121
Unit cell:
a: 44.09Å b: 77.82Å c: 119.97Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.163 0.162 0.189
Expression system: Escherichia coli