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Apo form of UIC2 Fab complex of human-mouse chimeric ABCB1 (ABCB1HM)

Electron Microscopy
4.14Å resolution
PDB entry 6fn4 coloured by chain, front view.
PDB entry 6fn4 coloured by chain, side view.
PDB entry 6fn4 coloured by chain, top view.
Source organisms:
Assembly composition:
hetero trimer (preferred)
Entry contents: 3 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: ATP-dependent translocase ABCB1 and IG-light kappa chain and IG-heavy chain
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Multimeric state: hetero trimer
Accessible surface area: 75384.68 Å2
Buried surface area: 7941.56 Å2
Dissociation area: 3,093.15 Å2
Dissociation energy (ΔGdiss): 16.16 kcal/mol
Dissociation entropy (TΔSdiss): 28.2 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-209348

Macromolecules

ATP-dependent translocase ABCB1
Chain: A
Length: 1279 amino acids
Theoretical weight: 141.28 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P08183 (Residues: 1-1279; Coverage: 100%)
Gene names: ABCB1, MDR1, PGY1
Pfam:
InterPro:
ATP-dependent translocase ABCB1 in PDB entry 6fn4, assembly 1, front view.
ATP-dependent translocase ABCB1 in PDB entry 6fn4, assembly 1, side view.
ATP-dependent translocase ABCB1 in PDB entry 6fn4, assembly 1, top view.
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UIC2 Antigen Binding Fragment Light chain
Chain: B
Length: 220 amino acids
Theoretical weight: 24.32 KDa
Source organism: Mus musculus
Expression system: Mus musculus
InterPro:
UIC2 Antigen Binding Fragment Light chain in PDB entry 6fn4, assembly 1, front view.
UIC2 Antigen Binding Fragment Light chain in PDB entry 6fn4, assembly 1, side view.
UIC2 Antigen Binding Fragment Light chain in PDB entry 6fn4, assembly 1, top view.
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UIC2 Antigen binding fragment Heavy chain
Chain: C
Length: 225 amino acids
Theoretical weight: 24.38 KDa
Source organism: Mus musculus
Expression system: Mus musculus
InterPro:
UIC2 Antigen binding fragment Heavy chain in PDB entry 6fn4, assembly 1, front view.
UIC2 Antigen binding fragment Heavy chain in PDB entry 6fn4, assembly 1, side view.
UIC2 Antigen binding fragment Heavy chain in PDB entry 6fn4, assembly 1, top view.
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