We've built a new version of this page with an interactive 3D viewer. Try it out in beta and help us improve:

› 6fhq

X-ray diffraction
1.95Å resolution

Crystal structure of human BAZ2B PHD zinc finger in complex with Fr 21

Released:
DOI: 10.2210/pdb6fhq/pdb
PDB entry 6fhq coloured by chain, front view.
PDB entry 6fhq coloured by chain, side view.
PDB entry 6fhq coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Targeting Ligandable Pockets on Plant Homeodomain (PHD) Zinc Finger Domains by a Fragment-Based Approach.
Amato A, Lucas X, Bortoluzzi A, Wright D, Ciulli A
OpenAccess logo ACS Chem Biol 13 915-921 (2018)
PMID: 29529862

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193783 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Bromodomain adjacent to zinc finger domain protein 2B Chains: A, B
Molecule details ›
Chains: A, B
Length: 58 amino acids
Theoretical weight: 6.54 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9UIF8 (Residues: 1928-1983; Coverage: 3%)
Gene names: BAZ2B, KIAA1476
Sequence domains: PHD-finger
Structure domains: Zinc/RING finger domain, C3HC4 (zinc finger)

Ligands and Environments

2 bound ligands:
Ligand ZN 4 x ZN
Ligand DE5 1 x DE5
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I24
Spacegroup: P212121
Unit cell:
a: 38.339Å b: 45.369Å c: 65.039Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.187 0.185 0.239
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

4 review citations

Targeting epigenetic protein-protein interactions with small-molecule inhibitors.
Linhares et al. (2020)
3 more

2 mentions without citation

Targeting Ligandable Pockets on Plant Homeodomain (PHD) Zinc Finger Domains by a Fragment-Based Approach.
Amato et al. (2018)
1 more