› 6fg2

X-ray diffraction
2.79Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-214049 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (5 distinct):
HEAVY CHAIN FAB NAA84 Chains: D, F
Molecule details ›
Chains: D, F
Length: 240 amino acids
Theoretical weight: 25.86 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
LIGHT CHAIN FAB NAA84 Chains: E, G
Molecule details ›
Chains: E, G
Length: 215 amino acids
Theoretical weight: 22.88 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
HEAVY CHAIN FAB NATALIZUMAB Chains: H, I
Molecule details ›
Chains: H, I
Length: 234 amino acids
Theoretical weight: 25.43 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
LIGHT CHAIN FAB NATALIZUMAB Chains: L, M
Molecule details ›
Chains: L, M
Length: 211 amino acids
Theoretical weight: 23.35 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE MASSIF-1
Spacegroup: P21
Unit cell:
a: 105.404Å b: 66.619Å c: 199.502Å
α: 90° β: 98.97° γ: 90°
R-values:
R R work R free
0.239 0.238 0.263
Expression system: Homo sapiens

Quick links

Citations

11 review citations

The Molecular Mechanisms That Underlie the Immune Biology of Anti-drug Antibody Formation Following Treatment With Monoclonal Antibodies.
Vaisman-Mentesh et al. (2020)
10 more

1 mention without citation

A single T cell epitope drives the neutralizing anti-drug antibody response to natalizumab in multiple sclerosis patients.
Cassotta et al. (2019)