6fad

X-ray diffraction
2.8Å resolution

SR protein kinase 1 (SRPK1) in complex with the RGG-box of HSV1 ICP27

Released:

Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-145213 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
SRSF protein kinase 1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 618 amino acids
Theoretical weight: 70.12 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q96SB4 (Residues: 42-655; Coverage: 94%)
Gene name: SRPK1
Sequence domains: Protein kinase domain
mRNA export factor Chains: E, F, G, H
Molecule details ›
Chains: E, F, G, H
Length: 16 amino acids
Theoretical weight: 1.75 KDa
Source organism: Human alphaherpesvirus 1 strain 17
Expression system: Not provided
UniProt:
  • Canonical: P10238 (Residues: 137-152; Coverage: 3%)
Gene name: UL54

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04-1
Spacegroup: P3212
Unit cell:
a: 99.98Å b: 99.98Å c: 426.049Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.201 0.198 0.257
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided