X-ray diffraction
2Å resolution

Co-crystal structure of SPOP MATH domain and human Pdx1 fragment


Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Speckle-type POZ protein Chain: D
Molecule details ›
Chain: D
Length: 145 amino acids
Theoretical weight: 16.62 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: O43791 (Residues: 28-166; Coverage: 37%)
Gene name: SPOP
Sequence domains: MATH domain
Structure domains: Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2; Chain A
Pancreas/duodenum homeobox protein 1 Chain: G
Molecule details ›
Chain: G
Length: 11 amino acids
Theoretical weight: 1.14 KDa
Source organism: Homo sapiens
Expression system: Not provided
  • Canonical: P52945 (Residues: 223-233; Coverage: 4%)
Gene names: IPF1, PDX1, STF1

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID30B
Spacegroup: P6522
Unit cell:
a: 53.925Å b: 53.925Å c: 207.41Å
α: 90° β: 90° γ: 120°
R R work R free
0.218 0.215 0.274
Expression systems:
  • Escherichia coli
  • Not provided