› 6f3c

X-ray diffraction
2.3Å resolution

The cytotoxic [Pt(H2bapbpy)] platinum complex interacting with the CGTACG hexamer

Released:
DOI: 10.2210/pdb6f3c/pdb
PDB 6f3c coloured by chain and viewed from the front.
PDB 6f3c coloured by chain and viewed from the side.
PDB 6f3c coloured by chain and viewed from the top.
Source organism: synthetic construct
Primary publication:
Induction of a four-way junction-like structure in the DNA palindromic hexanucleotide 5'-d(CGTACG)-3' by a mononuclear platinum complex.
van Rixel VHS, Busemann A, Wissingh MF, Hopkins SL, Siewert B, van de Griend C, Siegler MA, Marzo T, Papi F, Ferraroni M, Gratteri P, Bazzicalupi C, Messori L, Bonnet S
Angew. Chem. Int. Ed. Engl. (2019)
PMID: 31046177

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Entry contents:
2 distinct DNA molecules
Macromolecules (2 distinct):
DNA (5'-D(*GP*TP*AP*CP*G)-3') Chains: B, D
Molecule details ›
Chains: B, D
Length: 6 nucleotides
Theoretical weight: 1.81 KDa
Source organism: synthetic construct
Expression system: Not provided
DNA (5'-D(*GP*TP*AP*CP*G)-3') Chains: A, C
Molecule details ›
Chains: A, C
Length: 5 nucleotides
Theoretical weight: 1.52 KDa
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments

2 bound ligands:
Ligand MG 1 x MG
Ligand PT9 2 x PT9
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID30B
Spacegroup: P3221
Unit cell:
a: 30.09Å b: 30.09Å c: 116.99Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.261 0.257 0.292
Expression system: Not provided

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Citations

1 review citation

Ruthenium(II) Polypyridyl Complexes and Their Use as Probes and Photoreactive Agents for G-quadruplexes Labelling.
Jiang et al. (2022)
2 other articles