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Cryo-EM structure of TRIP13 in complex with ATP gamma S, p31comet, C-Mad2 and Cdc20

Electron Microscopy
4.6Å resolution
PDB entry 6f0x coloured by chain, front view.
PDB entry 6f0x coloured by chain, side view.
PDB entry 6f0x coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero nonamer (preferred)
Entry contents: 4 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero nonamer
Accessible surface area: 110223.73 Å2
Buried surface area: 36111.54 Å2
Dissociation area: 800.42 Å2
Dissociation energy (ΔGdiss): 3.72 kcal/mol
Dissociation entropy (TΔSdiss): 7.37 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-171410

Macromolecules

Pachytene checkpoint protein 2 homolog
Chains: A, B, C, D, E, F
Length: 432 amino acids
Theoretical weight: 48.61 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q15645 (Residues: 1-432; Coverage: 100%)
Gene names: PCH2, TRIP13
Pfam: ATPase family associated with various cellular activities (AAA)
InterPro:
Pachytene checkpoint protein 2 homolog in PDB entry 6f0x, assembly 1, front view.
Pachytene checkpoint protein 2 homolog in PDB entry 6f0x, assembly 1, side view.
Pachytene checkpoint protein 2 homolog in PDB entry 6f0x, assembly 1, top view.
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MAD2L1-binding protein
Chain: P
Length: 274 amino acids
Theoretical weight: 31.09 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q15013 (Residues: 1-274; Coverage: 100%)
Gene names: CMT2, KIAA0110, MAD2L1BP
Pfam: Mad1 and Cdc20-bound-Mad2 binding
InterPro: Mad1/Cdc20-bound-Mad2 binding protein
MAD2L1-binding protein in PDB entry 6f0x, assembly 1, front view.
MAD2L1-binding protein in PDB entry 6f0x, assembly 1, side view.
MAD2L1-binding protein in PDB entry 6f0x, assembly 1, top view.
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Cell division cycle protein 20 homolog
Chain: Q
Length: 499 amino acids
Theoretical weight: 54.8 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q12834 (Residues: 1-499; Coverage: 100%)
Gene name: CDC20
Pfam:
InterPro:
Cell division cycle protein 20 homolog in PDB entry 6f0x, assembly 1, front view.
Cell division cycle protein 20 homolog in PDB entry 6f0x, assembly 1, side view.
Cell division cycle protein 20 homolog in PDB entry 6f0x, assembly 1, top view.
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Mitotic spindle assembly checkpoint protein MAD2A
Chain: Z
Length: 205 amino acids
Theoretical weight: 23.53 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q13257 (Residues: 1-205; Coverage: 100%)
Gene names: MAD2, MAD2L1
Pfam: HORMA domain
InterPro:
Mitotic spindle assembly checkpoint protein MAD2A in PDB entry 6f0x, assembly 1, front view.
Mitotic spindle assembly checkpoint protein MAD2A in PDB entry 6f0x, assembly 1, side view.
Mitotic spindle assembly checkpoint protein MAD2A in PDB entry 6f0x, assembly 1, top view.
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