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PI3 kinase delta in complex with 4-Fluorophenyl 5-(4-(5-((4-isopropylpiperazin-1-yl)methyl)oxazol-2-yl)-1H-indazol-6-yl)-2-methoxynicotinate

Source organism: Mus musculus
Biochemical function: 1-phosphatidylinositol-3-kinase activity
Biological process: phosphatidylinositol phosphate biosynthetic process
Cellular component: not assigned

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EC 2.7.1.153: Phosphatidylinositol-4,5-bisphosphate 3-kinase

Reaction catalysed:
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
Systematic name:
ATP:1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate 3-phosphotransferase
Alternative Name(s):
  • Type I phosphoinositide 3-kinase

EC 2.7.1.137: Phosphatidylinositol 3-kinase

Reaction catalysed:
ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
Systematic name:
ATP:1-phosphatidyl-1D-myo-inositol 3-phosphotransferase
Alternative Name(s):
  • 1-phosphatidylinositol 3-kinase
  • PI3-kinase
  • PtdIns-3-kinase
  • Type I phosphatidylinositol kinase
  • Type III phosphoinositide 3-kinase
  • Vps34p

GO terms

Sequence families

Pfam Protein families (Pfam)
PF00454
Domain description: Phosphatidylinositol 3- and 4-kinase
Occurring in:
  1. Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
The deposited structure of PDB entry 6eyz contains 1 copy of Pfam domain PF00454 (Phosphatidylinositol 3- and 4-kinase) in Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform. Showing 1 copy in chain A.

PF00613
Domain description: Phosphoinositide 3-kinase family, accessory domain (PIK domain)
Occurring in:
  1. Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
The deposited structure of PDB entry 6eyz contains 1 copy of Pfam domain PF00613 (Phosphoinositide 3-kinase family, accessory domain (PIK domain)) in Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform. Showing 1 copy in chain A.

PF00792
Domain description: Phosphoinositide 3-kinase C2
Occurring in:
  1. Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
The deposited structure of PDB entry 6eyz contains 1 copy of Pfam domain PF00792 (Phosphoinositide 3-kinase C2) in Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform. Showing 1 copy in chain A.

PF00794
Domain description: PI3-kinase family, ras-binding domain
Occurring in:
  1. Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
The deposited structure of PDB entry 6eyz contains 1 copy of Pfam domain PF00794 (PI3-kinase family, ras-binding domain) in Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform. Showing 1 copy in chain A.

PF02192
Domain description: PI3-kinase family, p85-binding domain
Occurring in:
  1. Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
The deposited structure of PDB entry 6eyz contains 1 copy of Pfam domain PF02192 (PI3-kinase family, p85-binding domain) in Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR000403
Domain description: Phosphatidylinositol 3-/4-kinase, catalytic domain
Occurring in:
  1. Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
IPR001263
Domain description: Phosphoinositide 3-kinase, accessory (PIK) domain
Occurring in:
  1. Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
IPR002420
Domain description: C2 phosphatidylinositol 3-kinase-type domain
Occurring in:
  1. Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
IPR000341
Domain description: Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain
Occurring in:
  1. Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
IPR003113
Domain description: Phosphatidylinositol 3-kinase, adaptor-binding domain
Occurring in:
  1. Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
IPR018936
Domain description: Phosphatidylinositol 3/4-kinase, conserved site
Occurring in:
  1. Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
IPR035892
Domain description: C2 domain superfamily
Occurring in:
  1. Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
IPR036940
Domain description: Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily
Occurring in:
  1. Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
IPR011009
Domain description: Protein kinase-like domain superfamily
Occurring in:
  1. Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
IPR037703
Domain description: PI3Kdelta, catalytic domain
Occurring in:
  1. Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
IPR042236
Domain description: Phosphoinositide 3-kinase, accessory (PIK) domain superfamily
Occurring in:
  1. Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
IPR016024
Domain description: Armadillo-type fold
Occurring in:
  1. Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
IPR029071
Domain description: Ubiquitin-like domain superfamily
Occurring in:
  1. Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
IPR015433
Domain description: Phosphatidylinositol kinase
Occurring in:
  1. Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform

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