› 6eyk

X-ray diffraction
2.21Å resolution

E-selectin lectin, EGF-like and two SCR domains complexed with glycomimetic ligand NV355

Released:
DOI: 10.2210/pdb6eyk/pdb
PDB entry 6eyk coloured by chain, front view.
PDB entry 6eyk coloured by chain, side view.
PDB entry 6eyk coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Jakob RP, Zihlmann P, Preston RC, Varga N, Ernst B, Maier T

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-147771 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
E-selectin Chain: A
Molecule details ›
Chain: A
Length: 280 amino acids
Theoretical weight: 31.31 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P16581 (Residues: 22-301; Coverage: 48%)
Gene names: ELAM1, SELE
Sequence domains:
Structure domains:

Ligands and Environments

3 bound ligands:
Ligand NAG 7 x NAG
Ligand C5K 1 x C5K
Ligand CA 2 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: C2
Unit cell:
a: 93.52Å b: 73.08Å c: 52.45Å
α: 90° β: 94.19° γ: 90°
R-values:
R R work R free
0.23 0.229 0.245
Expression system: Cricetulus griseus

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