› 6exo

X-ray diffraction
1.9Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-188262 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cysteine protease Chains: A, B
Molecule details ›
Chains: A, B
Length: 215 amino acids
Theoretical weight: 22.92 KDa
Source organism: Trypanosoma brucei rhodesiense
Expression system: Komagataella pastoris
UniProt:
  • Canonical: Q95PM0 (Residues: 126-340; Coverage: 48%)
Gene name: rhodesain
Sequence domains: Papain family cysteine protease
Structure domains: Cysteine proteinases

Ligands and Environments

2 bound ligands:
Ligand EDO 23 x EDO
Ligand C3E 2 x C3E
1 modified residue:
Ligand CSX 2 x CSX

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID29
Spacegroup: P1
Unit cell:
a: 31.724Å b: 49.813Å c: 67.466Å
α: 103.86° β: 98.98° γ: 99.99°
R-values:
R R work R free
0.198 0.195 0.251
Expression system: Komagataella pastoris

Quick links

Citations

2 review citations

A Review of Small Molecule Inhibitors and Functional Probes of Human Cathepsin L.
Dana et al. (2020)
1 more

3 mentions without citation

Five new nortropane alkaloids and six new amino acids from the fruit of Morus alba LINNE growing in Turkey.
Kusano et al. (2002)
2 more