› › Structure analysis

Structure of Pragmin pseudo-kinase reveals a dimerization mechanism to regulate protein tyrosine phosphorylation and nuclear transcription

X-ray diffraction
2.771Å resolution
PDB entry 6ewx coloured by chain, front view.
PDB entry 6ewx coloured by chain, side view.
PDB entry 6ewx coloured by chain, top view.
Source organism: Rattus norvegicus
Assembly composition:
homo tetramer (preferred)
Entry contents: 1 distinct polypeptide molecule

Quick links

Assemblies

Assembly 1 (preferred)
Download    3D Visualisation
Assembly Name: Inactive tyrosine-protein kinase PRAG1
hide full assembly name
Multimeric state: homo tetramer
Accessible surface area: 66971.68 Å2
Buried surface area: 11868.05 Å2
Dissociation area: 1,652.37 Å2
Dissociation energy (ΔGdiss): 8.35 kcal/mol
Dissociation entropy (TΔSdiss): 15.23 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-112607

Macromolecules

Inactive tyrosine-protein kinase PRAG1
Chains: A, B
Length: 484 amino acids
Theoretical weight: 53.86 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli K-12
UniProt:
  • Canonical: D3ZMK9 (Residues: 906-1368; Coverage: 34%)
Gene names: Prag1, Pragmin
Pfam: Protein kinase domain
InterPro:
Inactive tyrosine-protein kinase PRAG1 in PDB entry 6ewx, assembly 1, front view.
Inactive tyrosine-protein kinase PRAG1 in PDB entry 6ewx, assembly 1, side view.
Inactive tyrosine-protein kinase PRAG1 in PDB entry 6ewx, assembly 1, top view.
Molecule details ›

Search similar proteins

Quick links