6euw

X-ray diffraction
1Å resolution

Crystal structure of the cap-binding domain of the PB2 subunit of influenza A/H5N1 polymerase bound to an azaindazole inhibitor

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Polymerase basic protein 2 Chain: A
Molecule details ›
Chain: A
Length: 163 amino acids
Theoretical weight: 18.25 KDa
Source organism: Influenza A virus (A/duck/Shantou/4610/2003(H5N1))
Expression system: Escherichia coli
UniProt:
  • Canonical: Q2LG68 (Residues: 318-483; Coverage: 21%)
Gene name: PB2
Sequence domains: Influenza RNA-dependent RNA polymerase subunit PB2

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-1
Spacegroup: P61
Unit cell:
a: 62.49Å b: 62.49Å c: 69.97Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.141 0.139 0.164
Expression system: Escherichia coli