6esa

X-ray diffraction
1.31Å resolution

Crystal Structure of the Protein-Kinase A catalytic subunit from Criteculus Griseus in complex with compounds RKp120 and AMP

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
cAMP-dependent protein kinase catalytic subunit alpha Chain: A
Molecule details ›
Chain: A
Length: 353 amino acids
Theoretical weight: 41.19 KDa
Source organism: Cricetulus griseus
Expression system: Escherichia coli 'BL21-Gold(DE3)pLysS AG'
UniProt:
  • Canonical: P25321 (Residues: 1-351; Coverage: 100%)
Gene name: PRKACA
Sequence domains: Protein kinase domain
UPF0418 protein FAM164A Chain: E
Molecule details ›
Chain: E
Length: 18 amino acids
Theoretical weight: 1.95 KDa
Source organism: Cricetulus griseus
Expression system: Not provided
UniProt:
  • Canonical: G3HK48 (Residues: 6-23; Coverage: 8%)
Gene name: I79_011066

Ligands and Environments

3 bound ligands:

2 modified residues:

Experiments and Validation Details

Entry percentile scores
X-ray source: BESSY BEAMLINE 14.2
Spacegroup: P212121
Unit cell:
a: 64.939Å b: 80.327Å c: 85.002Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.132 0.131 0.147
Expression systems:
  • Escherichia coli 'BL21-Gold(DE3)pLysS AG'
  • Not provided