› 6epw

X-ray diffraction
1.92Å resolution

The ATAD2 bromodomain in complex with compound UZH-DU32

Released:
DOI: 10.2210/pdb6epw/pdb
PDB 6epw coloured by chain and viewed from the front.
PDB 6epw coloured by chain and viewed from the side.
PDB 6epw coloured by chain and viewed from the top.
Source organism: Homo sapiens
Entry authors: Sledz P, Caflisch A

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
ATPase family AAA domain-containing protein 2 Chain: A
Molecule details ›
Chain: A
Length: 130 amino acids
Theoretical weight: 15.45 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q6PL18 (Residues: 981-1108; Coverage: 9%)
Gene names: ATAD2, L16, PRO2000
Sequence domains: Bromodomain
Structure domains: Bromodomain-like

Ligands and Environments

2 bound ligands:
Ligand BQ8 2 x BQ8
Ligand SO4 1 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P6522
Unit cell:
a: 79.072Å b: 79.072Å c: 139.764Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.224 0.223 0.243
Expression system: Escherichia coli

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