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DPP8 - SLRFLYEG, space group 20

Source organism: Homo sapiens
Biochemical function: hydrolase activity
Biological process: negative regulation of programmed cell death
Cellular component: cytosol

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EC 3.4.14.5: Dipeptidyl-peptidase IV

Reaction catalysed:
Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.
Alternative Name(s):
  • Amino acyl-prolyl dipeptidyl aminopeptidase
  • DPP IV
  • DPP IV/CD26
  • Dipeptidyl aminopeptidase IV
  • Dipeptidyl peptidase IV
  • Dipeptidyl-aminopeptidase IV
  • Dipeptidyl-peptide hydrolase
  • Gly-Pro naphthylamidase
  • Glycoprotein GP110
  • Glycylproline aminopeptidase
  • Glycylprolyl aminopeptidase
  • Glycylprolyl dipeptidylaminopeptidase
  • Leukocyte antigen CD26
  • Lymphocyte antigen CD26
  • Pep X
  • Post-proline dipeptidyl aminopeptidase IV
  • Postproline dipeptidyl aminopeptidase IV
  • T cell triggering molecule Tp103
  • X-PDAP
  • X-prolyl dipeptidyl aminopeptidase
  • Xaa-Pro-dipeptidyl-aminopeptidase
  • Xaa-Pro-dipeptidylaminopeptidase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF00326
Domain description: Prolyl oligopeptidase family
Occurring in:
  1. Dipeptidyl peptidase 8
The deposited structure of PDB entry 6eop contains 3 copies of Pfam domain PF00326 (Prolyl oligopeptidase family) in Dipeptidyl peptidase 8. Showing 1 copy in chain A.

PF00930
Domain description: Dipeptidyl peptidase IV (DPP IV) N-terminal region
Occurring in:
  1. Dipeptidyl peptidase 8
The deposited structure of PDB entry 6eop contains 3 copies of Pfam domain PF00930 (Dipeptidyl peptidase IV (DPP IV) N-terminal region) in Dipeptidyl peptidase 8. Showing 1 copy in chain A.

PF19520
Domain description: Dipeptidyl peptidase 8 and 9 N-terminal
Occurring in:
  1. Dipeptidyl peptidase 8
The deposited structure of PDB entry 6eop contains 3 copies of Pfam domain PF19520 (Dipeptidyl peptidase 8 and 9 N-terminal) in Dipeptidyl peptidase 8. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR029058
Domain description: Alpha/Beta hydrolase fold
Occurring in:
  1. Dipeptidyl peptidase 8
IPR001375
Domain description: Peptidase S9, prolyl oligopeptidase, catalytic domain
Occurring in:
  1. Dipeptidyl peptidase 8
IPR002469
Domain description: Dipeptidylpeptidase IV, N-terminal domain
Occurring in:
  1. Dipeptidyl peptidase 8
IPR045785
Domain description: Dipeptidyl peptidase 8 /9 ,N-terminal
Occurring in:
  1. Dipeptidyl peptidase 8

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