› 6eoh

X-ray diffraction
1.85Å resolution

Reductive Aminase from Aspergillus terreus in complex with NADPH and ethyl levulinate

Released:
DOI: 10.2210/pdb6eoh/pdb
PDB 6eoh coloured by chain and viewed from the front.
PDB 6eoh coloured by chain and viewed from the side.
PDB 6eoh coloured by chain and viewed from the top.
Source organism: Aspergillus terreus
Primary publication:
A Mechanism for Reductive Amination Catalyzed by Fungal Reductive Aminases
Sharma M, Mangas-Sanchez J, Turner NJ, Grogan G
ACS Catalysis (2018)

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
NAD_binding_2 domain-containing protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 298 amino acids
Theoretical weight: 30.76 KDa
Source organism: Aspergillus terreus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q0CCT3 (Residues: 1-298; Coverage: 100%)
Gene name: ATEG_08501
Sequence domains: NAD binding domain of 6-phosphogluconate dehydrogenase
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand NAP 2 x NAP
Ligand BKQ 1 x BKQ
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: P21
Unit cell:
a: 38.95Å b: 162.954Å c: 48.155Å
α: 90° β: 106.84° γ: 90°
R-values:
R R work R free
0.219 0.217 0.255
Expression system: Escherichia coli

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