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Solution structure of the LEDGF/p75 IBD - IWS1 (aa 446-548) complex

Solution NMR
PDB entry 6emr coloured by chain, ensemble of 40 models, front view.
PDB entry 6emr coloured by chain, ensemble of 40 models, side view.
PDB entry 6emr coloured by chain, ensemble of 40 models, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: PC4 and SFRS1-interacting protein, Protein IWS1 homolog
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Multimeric state: monomeric
Accessible surface area: 16878.46 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-130984

Macromolecules

PC4 and SFRS1-interacting protein; Protein IWS1 homolog
Chain: A
Length: 206 amino acids
Theoretical weight: 23.84 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O75475 (Residues: 345-442; Coverage: 19%)
  • Canonical: Q96ST2 (Residues: 447-548; Coverage: 13%)
    • nullnull
Gene names: DFS70, IWS1, IWS1L, LEDGF, PSIP1, PSIP2
Pfam: Lens epithelium-derived growth factor (LEDGF)
InterPro:
PC4 and SFRS1-interacting protein in PDB entry 6emr, assembly 1, front view.
PC4 and SFRS1-interacting protein in PDB entry 6emr, assembly 1, side view.
PC4 and SFRS1-interacting protein in PDB entry 6emr, assembly 1, top view.
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