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Tryptophan Repressor TrpR from E.coli wildtype with Indole-3-acetic acid as ligand

X-ray diffraction
1.99Å resolution
PDB entry 6ejw coloured by chain, front view.
PDB entry 6ejw coloured by chain, side view.
PDB entry 6ejw coloured by chain, top view.
Source organism: Escherichia coli
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1
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Assembly Name: Trp operon repressor
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Multimeric state: homo dimer
Accessible surface area: 10902.0 Å2
Buried surface area: 6067.87 Å2
Dissociation area: 2,647.64 Å2
Dissociation energy (ΔGdiss): 26.33 kcal/mol
Dissociation entropy (TΔSdiss): 12.31 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-141677
Assembly 2 (preferred)
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Assembly Name: Trp operon repressor
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Multimeric state: homo dimer
Accessible surface area: 11069.55 Å2
Buried surface area: 5771.78 Å2
Dissociation area: 2,468.7 Å2
Dissociation energy (ΔGdiss): 32.35 kcal/mol
Dissociation entropy (TΔSdiss): 12.23 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-141677

Macromolecules

Trp operon repressor
Chains: A, B, C, D
Length: 116 amino acids
Theoretical weight: 13.44 KDa
Source organism: Escherichia coli
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P0A881 (Residues: 1-108; Coverage: 100%)
Gene names: JW4356, b4393, rtrY, trpR
Pfam: Trp repressor protein
InterPro:
CATH: TrpR-like
Trp operon repressor in PDB entry 6ejw, assembly 2, front view.
Trp operon repressor in PDB entry 6ejw, assembly 2, side view.
Trp operon repressor in PDB entry 6ejw, assembly 2, top view.
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