› 6eiz

X-ray diffraction
1.85Å resolution

A de novo designed hexameric coiled coil CC-Hex2 with farnesol bound in the channel.

Released:
DOI: 10.2210/pdb6eiz/pdb
PDB 6eiz coloured by chain and viewed from the front.
PDB 6eiz coloured by chain and viewed from the side.
PDB 6eiz coloured by chain and viewed from the top.
Source organism: synthetic construct
Primary publication:
De novo designed α-helical barrels as receptors for small molecules.
Thomas F, Dawson WM, Lang EJM, Burton AJ, Bartlett GJ, Rhys G, Mulholland AJ, Woolfson DN
ACS Synth Biol (2018)
PMID: 29944338

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo hexamer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
CC-Hex2 Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 32 amino acids
Theoretical weight: 3.3 KDa
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand FOF 1 x FOF
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04-1
Spacegroup: C2221
Unit cell:
a: 59.08Å b: 126.23Å c: 58.24Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.223 0.221 0.258
Expression system: Not provided

Quick links

Citations

2 review citations

Recent Progress Using De Novo Design to Study Protein Structure, Design and Binding Interactions.
Ferrando et al. (2021)
1 more