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Coxsackievirus A24v in complex with the D1-D2 fragment of ICAM-1

Electron Microscopy
3.9Å resolution
PDB entry 6eit coloured by chain, front view.
PDB entry 6eit coloured by chain, side view.
PDB entry 6eit coloured by chain, top view.
Source organisms:
Assembly composition:
hetero 240-mer (preferred)
Entry contents: 4 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Intercellular adhesion molecule 1 and Coxsackievirus capsid protein VP1
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Multimeric state: hetero 240-mer
PDBe Complex ID: PDB-CPX-138638

Macromolecules

VP1
Chain: 1
Length: 305 amino acids
Theoretical weight: 34.38 KDa
Source organism: Coxsackievirus A24
UniProt:
  • Canonical: V9VEF3 (Residues: 581-885; Coverage: 14%)
Pfam: picornavirus capsid protein
InterPro:
CATH: Jelly Rolls
VP1 in PDB entry 6eit, assembly 1, front view.
VP1 in PDB entry 6eit, assembly 1, side view.
VP1 in PDB entry 6eit, assembly 1, top view.
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VP2
Chain: 2
Length: 271 amino acids
Theoretical weight: 29.82 KDa
Source organism: Coxsackievirus A24
UniProt:
  • Canonical: V9VEF3 (Residues: 70-340; Coverage: 12%)
Pfam: picornavirus capsid protein
InterPro:
CATH: Jelly Rolls
VP2 in PDB entry 6eit, assembly 1, front view.
VP2 in PDB entry 6eit, assembly 1, side view.
VP2 in PDB entry 6eit, assembly 1, top view.
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VP3
Chain: 3
Length: 240 amino acids
Theoretical weight: 26.64 KDa
Source organism: Coxsackievirus A24
UniProt:
  • Canonical: V9VEF3 (Residues: 341-580; Coverage: 11%)
Pfam: picornavirus capsid protein
InterPro:
CATH: Jelly Rolls
VP3 in PDB entry 6eit, assembly 1, front view.
VP3 in PDB entry 6eit, assembly 1, side view.
VP3 in PDB entry 6eit, assembly 1, top view.
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Intercellular adhesion molecule 1
Chain: 4
Length: 85 amino acids
Theoretical weight: 9.3 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P05362 (Residues: 28-112; Coverage: 17%)
Gene name: ICAM1
Pfam: Intercellular adhesion molecule (ICAM), N-terminal domain
InterPro:
CATH: Immunoglobulins
Intercellular adhesion molecule 1 in PDB entry 6eit, assembly 1, front view.
Intercellular adhesion molecule 1 in PDB entry 6eit, assembly 1, side view.
Intercellular adhesion molecule 1 in PDB entry 6eit, assembly 1, top view.
Molecule details ›

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