› › Structure analysis

Crystal structure of the inactive unphosphorylated IRAK4 kinase domain bound to AMP-PNP

X-ray diffraction
2.61Å resolution
PDB entry 6egf coloured by chain, front view.
PDB entry 6egf coloured by chain, side view.
PDB entry 6egf coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

Quick links

Assemblies

Assembly 1 (preferred)
Download    3D Visualisation
Assembly Name: Interleukin-1 receptor-associated kinase 4
hide full assembly name
Multimeric state: monomeric
Accessible surface area: 13263.67 Å2
Buried surface area: 1373.83 Å2
Dissociation area: 452.56 Å2
Dissociation energy (ΔGdiss): 3.75 kcal/mol
Dissociation entropy (TΔSdiss): 5.33 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-192669

Macromolecules

Interleukin-1 receptor-associated kinase 4
Chain: B
Length: 302 amino acids
Theoretical weight: 33.72 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q9NWZ3 (Residues: 164-460; Coverage: 65%)
Gene name: IRAK4
Pfam: Protein tyrosine and serine/threonine kinase
InterPro:
CATH:
Interleukin-1 receptor-associated kinase 4 in PDB entry 6egf, assembly 1, front view.
Interleukin-1 receptor-associated kinase 4 in PDB entry 6egf, assembly 1, side view.
Interleukin-1 receptor-associated kinase 4 in PDB entry 6egf, assembly 1, top view.
Molecule details ›

Search similar proteins

Quick links