› 6ebv

X-ray diffraction
3Å resolution

Staphylococcus aureus Type II pantothenate kinase in complex with ADP and pantothenate analog Deoxy-N7-Pan

Released:
DOI: 10.2210/pdb6ebv/pdb
PDB 6ebv coloured by chain and viewed from the front.
PDB 6ebv coloured by chain and viewed from the side.
PDB 6ebv coloured by chain and viewed from the top.
Source organism: Staphylococcus aureus
Entry authors: Chen Y, Antoshchenko T, Strauss E, Barnard L, Huang YH, Park H

Function and Biology Details

Reaction catalysed: 
ATP + (R)-pantothenate = ADP + (R)-4'-phosphopantothenate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Type II pantothenate kinase Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 267 amino acids
Theoretical weight: 29.13 KDa
Source organism: Staphylococcus aureus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q2FWC7 (Residues: 1-267; Coverage: 100%)
Gene names: SAOUHSC_02371, coaA, coaW
Sequence domains: Fumble

Ligands and Environments

2 bound ligands:
Ligand ADP 4 x ADP
Ligand 27Q 4 x 27Q
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-D
Spacegroup: P21
Unit cell:
a: 72.8Å b: 56.72Å c: 133.62Å
α: 90° β: 99.81° γ: 90°
R-values:
R R work R free
0.231 0.228 0.28
Expression system: Escherichia coli

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