› 6eal

X-ray diffraction
2.75Å resolution

CRYSTAL STRUCTURE OF HUMAN RESPIRATORY SYNCYTIAL VIRUS FUSION GLYCOPROTEIN INHIBITOR ESCAPE VARIANT D486N STABILIZED IN THE PREFUSION STATE

Released:
DOI: 10.2210/pdb6eal/pdb
PDB entry 6eal coloured by chain, front view.
PDB entry 6eal coloured by chain, side view.
PDB entry 6eal coloured by chain, top view.
Source organism: Human orthopneumovirus
Entry authors: Battles MB, McLellan JS

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136982 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Fusion glycoprotein F0 Chain: F
Molecule details ›
Chain: F
Length: 568 amino acids
Theoretical weight: 63.22 KDa
Source organism: Human orthopneumovirus
Expression system: Homo sapiens
UniProt:
  • Canonical: P03420 (Residues: 1-513; Coverage: 89%)
Gene name: F
Sequence domains: Fusion glycoprotein F0

Ligands and Environments

3 bound ligands:
Ligand TAR 3 x TAR
Ligand SO4 2 x SO4
Ligand NHE 1 x NHE
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-BM
Spacegroup: P4132
Unit cell:
a: 170.6Å b: 170.6Å c: 170.6Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.211 0.209 0.246
Expression system: Homo sapiens

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