› 6eae

X-ray diffraction
2.9Å resolution

CRYSTAL STRUCTURE OF HUMAN RESPIRATORY SYNCYTIAL VIRUS FUSION GLYCOPROTEIN INHIBITOR ESCAPE VARIANT L141W STABILIZED IN THE PREFUSION STATE

Released:
DOI: 10.2210/pdb6eae/pdb
PDB 6eae coloured by chain and viewed from the front.
PDB 6eae coloured by chain and viewed from the side.
PDB 6eae coloured by chain and viewed from the top.
Source organism: Human orthopneumovirus
Entry authors: Battles MB, McLellan JS

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Fusion glycoprotein F0 Chain: F
Molecule details ›
Chain: F
Length: 573 amino acids
Theoretical weight: 63.83 KDa
Source organism: Human orthopneumovirus
Expression system: Homo sapiens
UniProt:
  • Canonical: P03420 (Residues: 1-513; Coverage: 89%)
Gene name: F

Ligands and Environments

2 bound ligands:
Ligand SO4 5 x SO4
Ligand NHE 2 x NHE
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P4132
Unit cell:
a: 167.19Å b: 167.19Å c: 167.19Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.2 0.199 0.226
Expression system: Homo sapiens

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