6eae

X-ray diffraction
2.9Å resolution

CRYSTAL STRUCTURE OF HUMAN RESPIRATORY SYNCYTIAL VIRUS FUSION GLYCOPROTEIN INHIBITOR ESCAPE VARIANT L141W STABILIZED IN THE PREFUSION STATE

Released:
Source organism: Human orthopneumovirus
Entry authors: Battles MB, McLellan JS

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Fusion glycoprotein F0 Chain: F
Molecule details ›
Chain: F
Length: 573 amino acids
Theoretical weight: 63.83 KDa
Source organism: Human orthopneumovirus
Expression system: Homo sapiens
UniProt:
  • Canonical: P03420 (Residues: 1-513; Coverage: 89%)
Gene name: F

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P4132
Unit cell:
a: 167.19Å b: 167.19Å c: 167.19Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.2 0.199 0.226
Expression system: Homo sapiens