X-ray diffraction
2.45Å resolution

ERAP2 bound to Aryl Sulfonamide Uncompetitive Inhibitor

Source organism: Homo sapiens
Entry authors: Maben Z, Stern LJ

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (4 distinct):
Endoplasmic reticulum aminopeptidase 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 911 amino acids
Theoretical weight: 105.12 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
  • Canonical: Q6P179 (Residues: 53-960; Coverage: 95%)
Gene names: ERAP2, LRAP
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer : NEW Components: NAG, BMA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 31-ID
Spacegroup: P21
Unit cell:
a: 75.233Å b: 135.453Å c: 127.283Å
α: 90° β: 90.11° γ: 90°
R R work R free
0.209 0.208 0.236
Expression system: Trichoplusia ni