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Heterodimer of the GluN1b-GluN2B NMDA receptor amino-terminal domains bound to allosteric inhibitor 93-5

Source organisms:
Biochemical function: not assigned
Biological process: not assigned
Cellular component: not assigned

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GO terms

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF01094
Domain description: Receptor family ligand binding region
Occurring in:
  1. Glutamate receptor ionotropic, NMDA 1
  2. Glutamate receptor ionotropic, NMDA 2B
The deposited structure of PDB entry 6e7s contains 4 copies of Pfam domain PF01094 (Receptor family ligand binding region) in Glutamate receptor ionotropic, NMDA 1. Showing 2 copies in chain A.
The deposited structure of PDB entry 6e7s contains 2 copies of Pfam domain PF01094 (Receptor family ligand binding region) in Glutamate receptor ionotropic, NMDA 2B. Showing 1 copy in chain B.

InterPro InterPro annotations
IPR001828
Domain description: Receptor, ligand binding region
Occurring in:
  1. Glutamate receptor ionotropic, NMDA 1
  2. Glutamate receptor ionotropic, NMDA 2B
IPR028082
Domain description: Periplasmic binding protein-like I
Occurring in:
  1. Glutamate receptor ionotropic, NMDA 1
  2. Glutamate receptor ionotropic, NMDA 2B
IPR015683
Domain description: Ionotropic glutamate receptor
Occurring in:
  1. Glutamate receptor ionotropic, NMDA 2B
IPR000068
Domain description: GPCR, family 3, extracellular calcium-sensing receptor-related
Occurring in:
  1. Glutamate receptor ionotropic, NMDA 1

Structure domain

CATH CATH domain
3.40.50.2300
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: Rossmann fold
Occurring in:
  1. Glutamate receptor ionotropic, NMDA 1
  2. Glutamate receptor ionotropic, NMDA 2B
The deposited structure of PDB entry 6e7s contains 4 copies of CATH domain 3.40.50.2300 (Rossmann fold) in Glutamate receptor ionotropic, NMDA 1. Showing 2 copies in chain A.
The deposited structure of PDB entry 6e7s contains 4 copies of CATH domain 3.40.50.2300 (Rossmann fold) in Glutamate receptor ionotropic, NMDA 2B. Showing 2 copies in chain B.

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