6e75

X-ray diffraction
1.5Å resolution

Structure of Human Transthyretin Asp38Ala Mutant

Released:
Source organism: Homo sapiens
Entry authors: Chung K, Saelices L, Sawaya MR, Cascio D, Eisenberg D

Function and Biology Details

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transthyretin Chains: A, B
Molecule details ›
Chains: A, B
Length: 115 amino acids
Theoretical weight: 12.56 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P02766 (Residues: 30-144; Coverage: 91%)
Gene names: PALB, TTR
Sequence domains: HIUase/Transthyretin family

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: P21212
Unit cell:
a: 43.19Å b: 85.74Å c: 63.9Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.186 0.184 0.207
Expression system: Escherichia coli