› 6e5v

X-ray diffraction
2.95Å resolution

human mGlu8 receptor amino terminal domain in complex with (S)-3,4-Dicarboxyphenylglycine (DCPG)

Released:
DOI: 10.2210/pdb6e5v/pdb
PDB entry 6e5v coloured by chain, front view.
PDB entry 6e5v coloured by chain, side view.
PDB entry 6e5v coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural Basis for ( S)-3,4-Dicarboxyphenylglycine (DCPG) As a Potent and Subtype Selective Agonist of the mGlu8 Receptor.
Chen Q, Ho JD, Ashok S, Vargas MC, Wang J, Atwell S, Bures M, Schkeryantz JM, Monn JA, Hao J
J Med Chem 61 10040-10052 (2018)
PMID: 30365309

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-126167 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Metabotropic glutamate receptor 8 Chains: A, B
Molecule details ›
Chains: A, B
Length: 523 amino acids
Theoretical weight: 58.83 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: O00222 (Residues: 2-508; Coverage: 54%)
Gene names: GPRC1H, GRM8, MGLUR8
Sequence domains: Receptor family ligand binding region

Ligands and Environments

2 bound ligands:
Ligand HVG 2 x HVG
Ligand CL 2 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 31-ID
Spacegroup: P212121
Unit cell:
a: 82.945Å b: 106.78Å c: 117.908Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.258 0.255 0.306
Expression system: Spodoptera frugiperda

Quick links

Citations

1 review citation

Computational Drug Design Applied to the Study of Metabotropic Glutamate Receptors.
Llinas Del Torrent et al. (2019)