6e3u

X-ray diffraction
2.85Å resolution

Crystal Structure of the Heterodimeric HIF-2 Complex with Agonist M1001

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Aryl hydrocarbon receptor nuclear translocator Chain: A
Molecule details ›
Chain: A
Length: 384 amino acids
Theoretical weight: 43.44 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P53762 (Residues: 81-464; Coverage: 49%)
Gene name: Arnt
Sequence domains:
Endothelial PAS domain-containing protein 1 Chain: B
Molecule details ›
Chain: B
Length: 368 amino acids
Theoretical weight: 42.16 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P97481 (Residues: 3-362; Coverage: 41%)
Gene names: Epas1, Hif2a
Sequence domains:

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P21
Unit cell:
a: 48.951Å b: 98.846Å c: 77.077Å
α: 90° β: 107.2° γ: 90°
R-values:
R R work R free
0.202 0.199 0.258
Expression system: Escherichia coli BL21(DE3)