X-ray diffraction
1.5Å resolution

Structure of Elizabethkingia meningoseptica CdnE cyclic dinucleotide synthase with GTP and Apcpp


Function and Biology Details

Reactions catalysed:
2 ATP = 2 diphosphate + cyclic di-3',5'-adenylate
2 GTP = 2 diphosphate + cyclic di-3',5'-guanylate
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Cyclic dipurine nucleotide synthase Chain: A
Molecule details ›
Chain: A
Length: 292 amino acids
Theoretical weight: 34.2 KDa
Source organism: Elizabethkingia meningoseptica ATCC 13253 = NBRC 12535
Expression system: Escherichia coli
  • Canonical: P0DSP2 (Residues: 1-292; Coverage: 100%)
Gene names: NCTC10016_00133, cdnE01
Sequence domains: Second Messenger Oligonucleotide or Dinucleotide Synthetase domain

Ligands and Environments

3 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-E
Spacegroup: P212121
Unit cell:
a: 57.195Å b: 58.231Å c: 99.446Å
α: 90° β: 90° γ: 90°
R R work R free
0.156 0.155 0.18
Expression system: Escherichia coli