6dw1

Electron Microscopy
3.1Å resolution

Cryo-EM structure of the benzodiazepine-sensitive alpha1beta1gamma2S tri-heteromeric GABAA receptor in complex with GABA (ECD map)

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero pentamer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (7 distinct):
Gamma-aminobutyric acid receptor subunit gamma-2 Chain: D
Molecule details ›
Chain: D
Length: 490 amino acids
Theoretical weight: 56.89 KDa
Source organism: Rattus norvegicus
Expression system: Homo sapiens
UniProt:
  • Canonical: P18508 (Residues: 1-466; Coverage: 100%)
Gene name: Gabrg2
Sequence domains:
Gamma-aminobutyric acid receptor subunit alpha-1 Chains: A, C
Molecule details ›
Chains: A, C
Length: 402 amino acids
Theoretical weight: 46.27 KDa
Source organism: Rattus norvegicus
Expression system: Homo sapiens
UniProt:
  • Canonical: P62813 (Residues: 1-340, 409-455; Coverage: 84%)
Gene names: Gabra-1, Gabra1
Sequence domains: Neurotransmitter-gated ion-channel ligand binding domain
Gamma-aminobutyric acid receptor subunit beta-1 Chains: B, E
Molecule details ›
Chains: B, E
Length: 384 amino acids
Theoretical weight: 44.33 KDa
Source organism: Rattus norvegicus
Expression system: Homo sapiens
UniProt:
  • Canonical: P15431 (Residues: 1-333, 440-474; Coverage: 76%)
Gene names: Gabrb-1, Gabrb1
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer : NEW Components: NAG
1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.1Å
Relevant EMDB volumes: EMD-8923
Expression system: Homo sapiens