› 6dvr

X-ray diffraction
1.54Å resolution

Crystal structure of human CARM1 with (R)-SKI-72

Released:
DOI: 10.2210/pdb6dvr/pdb
PDB entry 6dvr coloured by chain, front view.
PDB entry 6dvr coloured by chain, side view.
PDB entry 6dvr coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Dong A, Zeng H, Hutchinson A, Seitova A, Luo M, Cai XC, Ke W, Wang J, Shi C, Zheng W, Lee JP, Ibanez G, Bountra C, Arrowsmith CH, Edwards AM, Brown PJ, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed: 
(1a) S-adenosyl-L-methionine + [protein]-L-arginine = S-adenosyl-L-homocysteine + [protein]-N(omega)-methyl-L-arginine
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
homo dimer (preferred)
homo octamer
Assembly name:
PDBe Complex ID:
PDB-CPX-183245 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Histone-arginine methyltransferase CARM1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 344 amino acids
Theoretical weight: 38.98 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q86X55 (Residues: 146-489; Coverage: 57%)
Gene names: CARM1, PRMT4
Sequence domains: Ribosomal protein L11 methyltransferase (PrmA)
Structure domains: Hnrnp arginine n-methyltransferase1

Ligands and Environments

3 bound ligands:
Ligand HDG 2 x HDG
Ligand P15 2 x P15
Ligand UNX 6 x UNX
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-E
Spacegroup: I222
Unit cell:
a: 74.366Å b: 98.579Å c: 207.375Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.195 0.195 0.215
Expression system: Spodoptera frugiperda

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