6duv

X-ray diffraction
1.8Å resolution

Crystal structure of the second bromodomain of human BRD4 in complex with MS417 inhibitor

Released:
Source organism: Homo sapiens
Entry authors: Babault N, Zhou MM

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Bromodomain-containing protein 4 Chains: A, B
Molecule details ›
Chains: A, B
Length: 112 amino acids
Theoretical weight: 13.04 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O60885 (Residues: 347-458; Coverage: 8%)
Gene names: BRD4, HUNK1
Sequence domains: Bromodomain

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X6A
Spacegroup: P3121
Unit cell:
a: 74.58Å b: 74.58Å c: 111.47Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.162 0.16 0.188
Expression system: Escherichia coli