› 6duv

X-ray diffraction
1.8Å resolution

Crystal structure of the second bromodomain of human BRD4 in complex with MS417 inhibitor

Released:
DOI: 10.2210/pdb6duv/pdb
PDB 6duv coloured by chain and viewed from the front.
PDB 6duv coloured by chain and viewed from the side.
PDB 6duv coloured by chain and viewed from the top.
Source organism: Homo sapiens
Entry authors: Babault N, Zhou MM

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Bromodomain-containing protein 4 Chains: A, B
Molecule details ›
Chains: A, B
Length: 112 amino acids
Theoretical weight: 13.04 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O60885 (Residues: 347-458; Coverage: 8%)
Gene names: BRD4, HUNK1
Sequence domains: Bromodomain

Ligands and Environments

2 bound ligands:
Ligand 0S6 3 x 0S6
Ligand EDO 7 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X6A
Spacegroup: P3121
Unit cell:
a: 74.58Å b: 74.58Å c: 111.47Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.162 0.16 0.188
Expression system: Escherichia coli

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