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Crystal structures of DNA polymerase I capture novel intermediates in the DNA synthesis pathway.

Chim N, Jackson LN, Trinh AM, Chaput JC
Elife 7 (2018)
Related entries: 6dsu, 6dsv, 6dsw, 6dsy

Cited: 10 times
EuropePMC logo PMID: 30338759

Abstract

High resolution crystal structures of DNA polymerase intermediates are needed to study the mechanism of DNA synthesis in cells. Here we report five crystal structures of DNA polymerase I that capture new conformations for the polymerase translocation and nucleotide pre-insertion steps in the DNA synthesis pathway. We suggest that these new structures, along with previously solved structures, highlight the dynamic nature of the finger subdomain in the enzyme active site.

Articles - 6dsx mentioned but not cited (1)

  1. Crystal structures of DNA polymerase I capture novel intermediates in the DNA synthesis pathway. Chim N, Jackson LN, Trinh AM, Chaput JC. Elife 7 e40444 (2018)


Articles citing this publication (9)

  1. Crystal structures of a natural DNA polymerase that functions as an XNA reverse transcriptase. Jackson LN, Chim N, Shi C, Chaput JC. Nucleic Acids Res 47 6973-6983 (2019)
  2. Rolling circle RNA synthesis catalyzed by RNA. Kristoffersen EL, Burman M, Noy A, Holliger P. Elife 11 e75186 (2022)
  3. Following replicative DNA synthesis by time-resolved X-ray crystallography. Chim N, Meza RA, Trinh AM, Yang K, Chaput JC. Nat Commun 12 2641 (2021)
  4. In Vitro Selection of an ATP-Binding TNA Aptamer. Zhang L, Chaput JC. Molecules 25 E4194 (2020)
  5. Mycobacterial DNA polymerase I: activities and crystal structures of the POL domain as apoenzyme and in complex with a DNA primer-template and of the full-length FEN/EXO-POL enzyme. Ghosh S, Goldgur Y, Shuman S. Nucleic Acids Res 48 3165-3180 (2020)
  6. Enzymatic Cleavage of 3'-Esterified Nucleotides Enables a Long, Continuous DNA Synthesis. LinWu SW, Tsai TY, Tu YH, Chi HW, Tsao YP, Chen YC, Wang HM, Chang WH, Chiou CF, Lee J, Chen CY. Sci Rep 10 7515 (2020)
  7. Biological and genomic characteristics of two bacteriophages isolated from sewage, using one multidrug-resistant and one non-multidrug-resistant strain of Klebsiella pneumoniae. Liang B, Zhao W, Han B, Barkema HW, Niu YD, Liu Y, Kastelic JP, Gao J. Front Microbiol 13 943279 (2022)
  8. Molecular Characterization of a DNA Polymerase from Thermus thermophilus MAT72 Phage vB_Tt72: A Novel Type-A Family Enzyme with Strong Proofreading Activity. Dorawa S, Werbowy O, Plotka M, Kaczorowska AK, Makowska J, Kozlowski LP, Fridjonsson OH, Hreggvidsson GO, Aevarsson A, Kaczorowski T. Int J Mol Sci 23 7945 (2022)
  9. Quality of Edible Sesame Oil as Obtained by Green Solvents: In Silico versus Experimental Screening Approaches. Trad S, Chaabani E, Aidi Wannes W, Dakhlaoui S, Nait Mohamed S, Khammessi S, Hammami M, Bourgou S, Saidani Tounsi M, Fabiano-Tixier AS, Bettaieb Rebey I. Foods 12 3263 (2023)


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