› 6dnf

Electron Microscopy
3.2Å resolution

Cryo-EM structure of the mitochondrial calcium uniporter MCU from the fungus Cyphellophora europaea

Released:
DOI: 10.2210/pdb6dnf/pdb
PDB 6dnf coloured by chain and viewed from the front.
PDB 6dnf coloured by chain and viewed from the side.
PDB 6dnf coloured by chain and viewed from the top.
Source organism: Cyphellophora europaea CBS 101466
Primary publication:
Cryo-EM structures of fungal and metazoan mitochondrial calcium uniporters.
Baradaran R, Wang C, Siliciano AF, Long SB
Nature (2018)
PMID: 29995857
Related structures: EMD-7971

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Calcium uniporter protein Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 352 amino acids
Theoretical weight: 39.64 KDa
Source organism: Cyphellophora europaea CBS 101466
Expression system: Komagataella pastoris
UniProt:
  • Canonical: W2SDE2 (Residues: 1-346; Coverage: 100%)
Gene name: HMPREF1541_00236
Sequence domains: Mitochondrial calcium uniporter

Ligands and Environments

2 bound ligands:
Ligand DGG 8 x DGG
Ligand CA 3 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.2Å
Relevant EMDB volumes: EMD-7971
Expression system: Komagataella pastoris

Quick links

Citations

13 review citations

Chloroplast Calcium Signaling in the Spotlight.
Navazio et al. (2020)
12 more

2 mentions without citation

Cryo-EM structures of fungal and metazoan mitochondrial calcium uniporters.
Baradaran et al. (2018)
1 more