Electron Microscopy
3.2Å resolution

Cryo-EM structure of the mitochondrial calcium uniporter MCU from the fungus Cyphellophora europaea


Function and Biology Details

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Entry contents:
1 distinct polypeptide molecule
Calcium uniporter protein Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 352 amino acids
Theoretical weight: 39.64 KDa
Source organism: Cyphellophora europaea CBS 101466
Expression system: Komagataella pastoris
  • Canonical: W2SDE2 (Residues: 1-346; Coverage: 100%)
Gene name: HMPREF1541_00236
Sequence domains: Mitochondrial calcium uniporter

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.2Å
Relevant EMDB volumes: EMD-7971
Expression system: Komagataella pastoris