› 6dm0

Electron Microscopy
4.4Å resolution

Open state GluA2 in complex with STZ and blocked by IEM-1460, after micelle signal subtraction

Released:
DOI: 10.2210/pdb6dm0/pdb
PDB entry 6dm0 coloured by chain, front view.
PDB entry 6dm0 coloured by chain, side view.
PDB entry 6dm0 coloured by chain, top view.
Source organisms:
Primary publication:
Mechanisms of Channel Block in Calcium-Permeable AMPA Receptors.
Twomey EC, Yelshanskaya MV, Vassilevski AA, Sobolevsky AI
Neuron 99 956-968.e4 (2018)
PMID: 30122377
Related structures: EMD-7960

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148603 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutamate receptor 2; Voltage-dependent calcium channel gamma-2 subunit Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 1031 amino acids
Theoretical weight: 115.18 KDa
Source organisms: Expression system: Homo sapiens
UniProt:
  • Canonical: P19491 (Residues: 25-847; Coverage: 95%)
  • Canonical: Q9Y698 (Residues: 2-208; Coverage: 64%)
Gene names: CACNG2, GluA2, Glur2, Gria2
Sequence domains:

Ligands and Environments

3 bound ligands:
Ligand GLU 4 x GLU
Ligand CYZ 4 x CYZ
Ligand GZD 1 x GZD
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 4.4Å
Relevant EMDB volumes: EMD-7960
Expression system: Homo sapiens

Quick links

Citations

13 review citations

Structure, Function, and Pharmacology of Glutamate Receptor Ion Channels.
Hansen et al. (2021)
12 more

6 mentions without citation

Diversity of AMPA Receptor Ligands: Chemotypes, Binding Modes, Mechanisms of Action, and Therapeutic Effects.
Golubeva et al. (2022)
5 more