X-ray diffraction
4Å resolution

Crystal structure of LRRK2 WD40 domain dimer

Source organism: Homo sapiens
Primary publication:
Crystal structure of the WD40 domain dimer of LRRK2.
Proc. Natl. Acad. Sci. U.S.A. (2019)
PMID: 30635421

Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Leucine-rich repeat serine/threonine-protein kinase 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 389 amino acids
Theoretical weight: 43.67 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
  • Canonical: Q5S007 (Residues: 2142-2527; Coverage: 15%)
Gene names: LRRK2, PARK8

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: P212121
Unit cell:
a: 79.293Å b: 103.59Å c: 112.664Å
α: 90° β: 90° γ: 90°
R R work R free
0.23 0.228 0.263
Expression system: Spodoptera frugiperda