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Crystal structure of primase iron-sulfur domain (266-457)

X-ray diffraction
2.013Å resolution
PDB entry 6dhw coloured by chain, front view.
PDB entry 6dhw coloured by chain, side view.
PDB entry 6dhw coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: DNA primase large subunit
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Multimeric state: homo dimer
Accessible surface area: 17745.17 Å2
Buried surface area: 3592.34 Å2
Dissociation area: 920.41 Å2
Dissociation energy (ΔGdiss): 7.51 kcal/mol
Dissociation entropy (TΔSdiss): 11.98 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-155976
Assembly 2
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Assembly Name: DNA primase large subunit
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Multimeric state: homo dimer
Accessible surface area: 17421.58 Å2
Buried surface area: 3920.78 Å2
Dissociation area: 1,069.5 Å2
Dissociation energy (ΔGdiss): 19.39 kcal/mol
Dissociation entropy (TΔSdiss): 11.85 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-155976

Macromolecules

DNA primase large subunit
Chains: A, B
Length: 192 amino acids
Theoretical weight: 22.08 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P49643 (Residues: 266-457; Coverage: 38%)
Gene names: PRIM2, PRIM2A
Pfam: Eukaryotic and archaeal DNA primase, large subunit
InterPro:
DNA primase large subunit in PDB entry 6dhw, assembly 1, front view.
DNA primase large subunit in PDB entry 6dhw, assembly 1, side view.
DNA primase large subunit in PDB entry 6dhw, assembly 1, top view.
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