PDBe 6dgq

X-ray diffraction
2.45Å resolution

Crystal Structure of Human PPARgamma Ligand Binding Domain in Complex with CAY10506

Released:
Source organism: Homo sapiens
Entry authors: Shang J, Kojetin DJ

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peroxisome proliferator-activated receptor gamma Chains: A, B
Molecule details ›
Chains: A, B
Length: 276 amino acids
Theoretical weight: 31.51 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P37231 (Residues: 231-505; Coverage: 55%)
Gene names: NR1C3, PPARG
Sequence domains: Ligand-binding domain of nuclear hormone receptor

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.2
Spacegroup: C2
Unit cell:
a: 92.2Å b: 59.49Å c: 116.73Å
α: 90° β: 103.55° γ: 90°
R-values:
R R work R free
0.196 0.191 0.247
Expression system: Escherichia coli BL21(DE3)