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Crystal structure of ternary complex of IL-24 with soluble receptors IL-22RA and IL-20RB

X-ray diffraction
2.15Å resolution
PDB entry 6df3 coloured by chain, front view.
PDB entry 6df3 coloured by chain, side view.
PDB entry 6df3 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero trimer (preferred)
Entry contents: 3 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero trimer
Accessible surface area: 26708.42 Å2
Buried surface area: 6106.08 Å2
Dissociation area: 2,416.76 Å2
Dissociation energy (ΔGdiss): -0.18 kcal/mol
Dissociation entropy (TΔSdiss): 25.55 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-171500

Macromolecules

Interleukin-22 receptor subunit alpha-1
Chain: L
Length: 206 amino acids
Theoretical weight: 23.56 KDa
Source organism: Homo sapiens
Expression system: Drosophila melanogaster
UniProt:
  • Canonical: Q8N6P7 (Residues: 24-228; Coverage: 37%)
Gene names: IL22R, IL22RA1
Pfam: Tissue factor
InterPro:
CATH: Immunoglobulins
Interleukin-22 receptor subunit alpha-1 in PDB entry 6df3, assembly 1, front view.
Interleukin-22 receptor subunit alpha-1 in PDB entry 6df3, assembly 1, side view.
Interleukin-22 receptor subunit alpha-1 in PDB entry 6df3, assembly 1, top view.
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Interleukin-24
Chain: C
Length: 155 amino acids
Theoretical weight: 18.2 KDa
Source organism: Homo sapiens
Expression system: Drosophila melanogaster
UniProt:
  • Canonical: Q13007 (Residues: 52-206; Coverage: 100%)
Gene names: IL24, MDA7, ST16
InterPro:
Interleukin-24 in PDB entry 6df3, assembly 1, front view.
Interleukin-24 in PDB entry 6df3, assembly 1, side view.
Interleukin-24 in PDB entry 6df3, assembly 1, top view.
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Interleukin-20 receptor subunit beta
Chain: H
Length: 190 amino acids
Theoretical weight: 21.37 KDa
Source organism: Homo sapiens
Expression system: Drosophila melanogaster
UniProt:
  • Canonical: Q6UXL0 (Residues: 35-224; Coverage: 67%)
Gene names: DIRS1, IL20RB, UNQ557/PRO1114
Pfam:
InterPro:
CATH: Immunoglobulins
Interleukin-20 receptor subunit beta in PDB entry 6df3, assembly 1, front view.
Interleukin-20 receptor subunit beta in PDB entry 6df3, assembly 1, side view.
Interleukin-20 receptor subunit beta in PDB entry 6df3, assembly 1, top view.
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