X-ray diffraction
1.5Å resolution

Crystal Structure of the human BRD2 BD1 bromodomain in complex with a Tetrahydroquinoline analogue


Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Bromodomain-containing protein 2 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 138 amino acids
Theoretical weight: 16.15 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
  • Canonical: P25440 (Residues: 67-200; Coverage: 17%)
  • Best match: P25440-4 (Residues: 1-80)
Gene names: BRD2, KIAA9001, RING3
Sequence domains: Bromodomain

Ligands and Environments

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-BM
Spacegroup: C2
Unit cell:
a: 118.01Å b: 55.851Å c: 66.613Å
α: 90° β: 94.17° γ: 90°
R R work R free
0.146 0.145 0.174
Expression system: Escherichia coli BL21(DE3)