Structure analysis

Tribbles (TRIB1) pseudokinase fused to CCAAT-enhancer binding protein (C/EBPalpha) degron

X-ray diffraction
2.8Å resolution
Source organism: Homo sapiens
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

Assemblies

Assembly 1 (preferred)
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Multimeric state: homo dimer
Accessible surface area: 25100 Å2
Buried surface area: 3900 Å2
Dissociation area: 2,000 Å2
Dissociation energy (ΔGdiss): 22 kcal/mol
Dissociation entropy (TΔSdiss): 13 kcal/mol
Interface energy (ΔGint): -18 kcal/mol
Symmetry number: 1

Macromolecules

Chains: A, B
Length: 292 amino acids
Theoretical weight: 32.81 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P49715 (Residues: 51-75; Coverage: 7%)
  • Canonical: Q96RU8 (Residues: 90-343; Coverage: 68%)
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Gene names: C8FW, CEBP, CEBPA, GIG2, TRB1, TRIB1
Pfam: Protein kinase domain
InterPro:

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