6dc0

X-ray diffraction
2.8Å resolution

Tribbles (TRIB1) pseudokinase fused to CCAAT-enhancer binding protein (C/EBPalpha) degron

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
CCAAT/enhancer-binding protein alpha; Tribbles homolog 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 292 amino acids
Theoretical weight: 32.81 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P49715 (Residues: 51-75; Coverage: 7%)
  • Canonical: Q96RU8 (Residues: 90-343; Coverage: 68%)
Gene names: C8FW, CEBP, CEBPA, GIG2, TRB1, TRIB1
Sequence domains: Protein kinase domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX2
Spacegroup: P6122
Unit cell:
a: 98.809Å b: 98.809Å c: 332.705Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.223 0.22 0.277
Expression system: Escherichia coli BL21(DE3)