6dbc

X-ray diffraction
1.05Å resolution

Second bromodomain of Human BRD2 with a Tetrahydroquinoline analogue

Released:
Source organism: Homo sapiens
Entry authors: White SW, Yun M

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Bromodomain-containing protein 2 Chain: A
Molecule details ›
Chain: A
Length: 115 amino acids
Theoretical weight: 13.52 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P25440 (Residues: 348-455; Coverage: 14%)
Gene names: BRD2, KIAA9001, RING3
Sequence domains: Bromodomain

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P21212
Unit cell:
a: 52.394Å b: 72.186Å c: 31.975Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.128 0.128 0.132
Expression system: Escherichia coli BL21(DE3)