› 6d7w

Electron Microscopy
3.8Å resolution

Cryo-EM structure of the mitochondrial calcium uniporter from N. fischeri at 3.8 Angstrom resolution

Released:
DOI: 10.2210/pdb6d7w/pdb
PDB entry 6d7w coloured by chain, front view.
PDB entry 6d7w coloured by chain, side view.
PDB entry 6d7w coloured by chain, top view.
Source organism: Aspergillus fischeri
Primary publication:
Cryo-EM structure of a fungal mitochondrial calcium uniporter.
Nguyen NX, Armache JP, Lee C, Yang Y, Zeng W, Mootha VK, Cheng Y, Bai XC, Jiang Y
Nature 559 570-574 (2018)
PMID: 29995855
Related structures: EMD-7826

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-106583 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Calcium uniporter protein Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 416 amino acids
Theoretical weight: 47.93 KDa
Source organism: Aspergillus fischeri
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: A1CWT6 (Residues: 75-488; Coverage: 85%)
Gene name: NFIA_105760
Sequence domains: Mitochondrial calcium uniporter

Ligands and Environments

1 bound ligand:
Ligand CA 1 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.8Å
Relevant EMDB volumes: EMD-7826
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

31 review citations

The machineries, regulation and cellular functions of mitochondrial calcium.
Giorgi et al. (2018)
30 more

5 mentions without citation

Structural characterization of the mitochondrial Ca2+ uniporter provides insights into Ca2+ uptake and regulation.
Wu et al. (2021)
4 more