X-ray diffraction
1.65Å resolution

The structure of ligand binding domain of LasR in complex with TP-1 homolog, compound 19


Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Transcriptional activator protein LasR Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 170 amino acids
Theoretical weight: 19.01 KDa
Source organism: Pseudomonas aeruginosa PAO1
Expression system: Escherichia coli
  • Canonical: P25084 (Residues: 1-170; Coverage: 71%)
Gene names: PA1430, lasR
Sequence domains: Autoinducer binding domain
Structure domains: Transcription factor LuxR-like, autoinducer-binding domain

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-F
Spacegroup: P21
Unit cell:
a: 56.13Å b: 84.61Å c: 77.17Å
α: 90° β: 101.41° γ: 90°
R R work R free
0.22 0.219 0.248
Expression system: Escherichia coli